Bioengineered Efficacy Models of Skin Disease: Advances in the Last 10 Years.
Bioengineered Efficacy Models of Skin Disease: Advances in the Last 10 Years.
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DOI：
10.3390/pharmaceutics14020319
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发表时间：
2022-01-28
期刊：
影响因子：
5.4
通讯作者：
Karande P
中科院分区：
文献类型：
--
作者：
Stanton DN;Ganguli-Indra G;Indra AK;Karande P
牛皮癣、硬皮病等皮肤病的模型必须准确再现人体皮肤复杂的微环境，为皮肤病的研究提供有效的平台。皮肤病研究已经从不太复杂和不太相关的2D（二维）模型转向相关性明显更高的3D（三维）模型。三维建模系统能够更好地概括复杂的细胞-细胞和细胞-基质的相互作用，发生在皮肤体内。三维人体皮肤等效物（HSEs）已成为体外研究皮肤病的有利工具。这些3D HSEs可能非常复杂，包含表皮和真皮隔室，并具有完整的附件结构。将附件结构添加到3D HSEs中，使研究人员能够更深入地了解各种遗传性和获得性皮肤病的复杂病理。3D生物打印是一种构建3D HSEs的方法，已成为生成高度复杂的HSEs的通用和有用的工具。商用3D生物打印机的发展使研究人员能够创建高度可复制的3D hse，并精确集成多个附属结构。虽然生物工程模型在皮肤病研究领域在过去十年中取得了巨大的进展，但仍有大量的努力需要创建真正的仿生皮肤病模型。在未来利用3D HSEs的研究中，重点必须放在整合与所研究的皮肤病相关的所有附件结构上。深入研究复杂的皮肤病病理和开发有效的治疗方法需要使用高效的皮肤病模型。
Models of skin diseases, such as psoriasis and scleroderma, must accurately recapitulate the complex microenvironment of human skin to provide an efficacious platform for investigation of skin diseases. Skin disease research has been shifting from less complex and less relevant 2D (two-dimensional) models to significantly more relevant 3D (three-dimensional) models. Three-dimensional modeling systems are better able to recapitulate the complex cell–cell and cell–matrix interactions that occur in vivo within skin. Three-dimensional human skin equivalents (HSEs) have emerged as an advantageous tool for the study of skin disease in vitro. These 3D HSEs can be highly complex, containing both epidermal and dermal compartments with integrated adnexal structures. The addition of adnexal structures to 3D HSEs has allowed researchers to gain more insight into the complex pathology of various hereditary and acquired skin diseases. One method of constructing 3D HSEs, 3D bioprinting, has emerged as a versatile and useful tool for generating highly complex HSEs. The development of commercially available 3D bioprinters has allowed researchers to create highly reproducible 3D HSEs with precise integration of multiple adnexal structures. While the field of bioengineered models for study of skin disease has made tremendous progress in the last decade, there are still significant efforts necessary to create truly biomimetic skin disease models. In future studies utilizing 3D HSEs, emphasis must be placed on integrating all adnexal structures relevant to the skin disease under investigation. Thorough investigation of the intricate pathology of skin diseases and the development of effective treatments requires use of highly efficacious models of skin diseases.
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影响因子：
2.1
作者：
Dudbridge F
通讯作者：
Dudbridge F
影响因子：
5.6
作者：
Bocheńska K;Smolińska E;Moskot M;Jakóbkiewicz-Banecka J;Gabig-Cimińska M
通讯作者：
Gabig-Cimińska M
影响因子：
9
作者：
Chau, David Y. S.;Johnson, Claire;Ghaemmaghami, Amir M.
通讯作者：
Ghaemmaghami, Amir M.
影响因子：
3.6
作者：
Desmet, Eline;Van Gele, Mireille;Lambert, Jo
通讯作者：
Lambert, Jo
影响因子：
4.5
作者：
Borodzicz S;Rudnicka L;Mirowska-Guzel D;Cudnoch-Jedrzejewska A
通讯作者：
Cudnoch-Jedrzejewska A