The limbic and neocortical contribution of α-synuclein, tau, and amyloid β to disease duration in dementia with Lewy bodies.
The limbic and neocortical contribution of α-synuclein, tau, and amyloid β to disease duration in dementia with Lewy bodies.
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DOI：
10.1016/j.jalz.2017.09.014
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Dickson DW
中科院分区：
文献类型：
--
作者：
Ferman TJ;Aoki N;Crook JE;Murray ME;Graff-Radford NR;van Gerpen JA;Uitti RJ;Wszolek ZK;Graff-Radford J;Pedraza O;Kantarci K;Boeve BF;Dickson DW
我们试图评估边缘系统和新皮质 α-突触核蛋白、tau 蛋白和 β-淀粉样蛋白对路易体痴呆病程的个体和综合贡献。对 49 名临床上可能患有路易体痴呆的患者进行了新皮质和边缘 α-突触核蛋白、tau 和 β-淀粉样蛋白的定量图像分析。回归模型检查了每种病理对病程方差的独特和共同贡献。与患有过渡性路易体病的患者相比，患有弥漫性路易体病的患者每种类型的病理学都更严重，并且病程更短。这三种病理占疾病持续时间总方差的 25%，其中 19% 是由 α-突触核蛋白单独或与 tau 和 β-淀粉样蛋白组合引起的。当单独检查弥漫性路易体病组时，α-突触核蛋白沉积超过了 tau 和 β-淀粉样蛋白，并且生存率与 tau 或 β-淀粉样蛋白负荷的差异无关。在此模型中，疾病持续时间模型中 24% 总方差中的 20% 由 α-突触核蛋白独立解释。在路易体痴呆中，α-突触核蛋白的负担是疾病持续时间的重要预测因子，既独立又与 tau 和 β-淀粉样蛋白协同作用。
We sought to assess the individual and combined contribution of limbic and neocortical α-synuclein, tau and β-amyloid to duration of illness in dementia with Lewy bodies. Quantitative image analysis of neocortical and limbic α-synuclein, tau and β-amyloid was assessed in 49 patients with clinically probable dementia with Lewy bodies. Regression modelling examined the unique and shared contribution of each pathology to the variance of illness duration. Patients with diffuse Lewy body disease had more severe pathology of each type and a shorter duration of illness than individuals with transitional Lewy body disease. The three pathologies accounted for 25% of the total variance of duration of illness, with 19% accounted for by α-synuclein alone or in combination with tau and β-amyloid. When the diffuse Lewy body disease group was examined separately, α-synuclein deposition exceeded that of tau and β-amyloid, and survival was not related to differences in tau or β-amyloid burden. In this model, 20% of 24% total variance in the model for duration of illness was accounted for independently by α-synuclein. In dementia with Lewy bodies, the burden of α-synuclein is an important predictor of disease duration, both independently and synergistically with tau and β-amyloid.
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影响因子：
12.7
作者：
Janocko NJ;Brodersen KA;Soto-Ortolaza AI;Ross OA;Liesinger AM;Duara R;Graff-Radford NR;Dickson DW;Murray ME
通讯作者：
Murray ME
影响因子：
4.8
作者：
Boeve, Bradley F.;Molano, Jennifer R.;Ferman, Tanis J.;Smith, Glenn E.;Lin, Siong-Chi;Bieniek, Kevin;Haidar, Wael;Tippmann-Peikert, Maja;Knopman, David S.;Graff-Radford, Neill R.;Lucas, John A.;Petersen, Ronald C.;Silber, Michael H.
通讯作者：
Silber, Michael H.
影响因子：
48
作者：
Irwin, David;Grossman, Murray;Weintraub, Daniel;Hurtig, Howard I.;Duda, John E.;Xie, Sharon X.;Lee, Edward B.;Van Deerlin, Vivianna M.;Lopez, Oscar L.;Kofler, Julia K.;Nelson, Peter T.;Jicha, Gregory A.;Woltjer, Randy;Quinn, Joseph F.;Kaye, Jeffery;Leverenz, James B.;Tsuang, Debby;Longfellow, Katelan;Yearout, Dora;Kukull, Walter;Keene, C. Dirk;Montine, Thomas J.;Zabetian, Cyrus P.;Trojanowski, John Q.
通讯作者：
Trojanowski, John Q.
影响因子：
12.7
作者：
Halliday, Glenda;Hely, Mariese;Morris, John
通讯作者：
Morris, John
影响因子：
2.5
作者：
Fujishiro, Hiroshige;Iseki, Eizo;Sato, Kiyoshi
通讯作者：
Sato, Kiyoshi