Ethnic differences in periodic limb movements during sleep in patients with restless legs syndrome: a preliminary cross-sectional study of Austrian and Japanese clinical population
Ethnic differences in periodic limb movements during sleep in patients with restless legs syndrome: a preliminary cross-sectional study of Austrian and Japanese clinical population
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不宁腿综合征患者睡眠期间周期性肢体运动的种族差异：奥地利和日本临床人群的初步横断面研究
DOI：
10.1007/s41105-018-0159-5
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发表时间：
2018
影响因子：
1.1
通讯作者：
Yuichi Inoue
中科院分区：
文献类型：
--
作者：
Taeko Sasai-Sakuma;Ambra Stefani;Moeko Ochi;Birgit Hogl;Yuichi Inoue
睡眠期间周期性肢体运动（PLMS）被认为是不宁腿综合征（RLS）患者的常见发现。尽管在西方国家超过80%的RLS患者中观察到PLMS，但对亚洲RLS患者知之甚少，并且没有关于日本患者的数据。本横断面研究旨在探讨奥地利和日本接受夜间多导睡眠图（n-PSG）的RLS患者在临床信息和多导睡眠图变量（包括PLMS）方面的种族差异。纳入100名奥地利和139名日本连续诊断为RLS并接受n-PSG的患者[奥地利54.5±13.6岁，40名女性（40%）；日本50.2±18.9岁，女性88例（63.3%）。回顾性回顾医疗记录和n-PSG数据。比较两组患者的流行病学、临床及n-PSG指标。奥地利RLS患者PLMS≥5/h和PLMS≥15/h的比例高于日本RLS患者（80.0比56.1%，P< 0.001； 55.0比41.7%，P= 0.043）。因此，日本RLS患者的PLMS指数低于奥地利患者（21.3比33.6/h，P= 0.008）。与奥地利患者相比，日本RLS患者女性优势度更高，BMI指数更低，收缩压/舒张压更低，铁蛋白水平更低，国际不宁腿综合征严重程度量表更高。在两组中，这些变量均与PLMS无关。与奥地利RLS患者相比，日本RLS患者的合并率和PLMS指标均显著降低。这项关于RLS患者PLMS的种族差异的横断面研究可能为未来欧洲和亚洲RLS患者之间的遗传比较研究提供桥梁。
Periodic limb movements during sleep (PLMS) are identified as a common finding in patients with restless legs syndrome (RLS). Although PLMS are observed in more than 80% of RLS patients in Western countries, little is known about Asian RLS patients and no data are available about Japanese patients. This cross-sectional study aimed to investigate ethnic differences in clinical information and polysomnographic variables including PLMS between Austrian and Japanese RLS patient undergoing nocturnal polysomnography (n-PSG). One hundred Austrian and 139 Japanese consecutive patients diagnosed with RLS who underwent n-PSG were included [Austrian 54.5 ± 13.6 years, 40 females (40%); Japanese 50.2 ± 18.9 years, 88 females (63.3%)]. Medical records and n-PSG data were reviewed retrospectively. Epidemiological, clinical and n-PSG variables were compared between the two groups. Rate of patients with PLMS ≥ 5/h and those with PLMS ≥ 15/h were higher in Austrian than in Japanese RLS patients (80.0 vs. 56.1%,P< 0.001; 55.0 vs. 41.7%,P= 0.043). Accordingly, Japanese RLS patients showed lower PLMS index than Austrian patients (21.3 vs. 33.6/h,P= 0.008). Japanese RLS patients showed higher female predominance, lower BMI, lower systolic/diastolic blood pressure, lower ferritin level and higher International restless legs syndrome severity scale than Austrian patients. None of these variables were associated with PLMS in both groups. Japanese RLS patients showed significantly lower comorbidity rate and lower indices of PLMS compared to Austrian RLS patients. This cross-sectional study on ethnic differences in PLMS in patients with RLS may provide a bridge to a future genetic comparative study between European and Asian RLS patients.
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影响因子：
10.5
作者：
Ohayon MM;O'Hara R;Vitiello MV
通讯作者：
Vitiello MV
影响因子：
5.6
作者：
Moore, Hyatt;Winkelmann, Juliane;Mignot, Emmanuel
通讯作者：
Mignot, Emmanuel
铁储备低的不宁腿综合征患者与铁储备正常的患者之间的周期性腿部运动是否存在差异？
影响因子：
4.8
作者：
A. Heidbreder;A. Stefani;T. Mitterling;P. Weiss;E. Brandauer;B. Högl
通讯作者：
B. Högl
周期性肢体运动 (PLM) 的复兴：腿部活动监测和不宁腿综合症 (RLS)。
影响因子：
4.8
作者：
R. Allen
通讯作者：
R. Allen
睡眠期间周期性肢体运动：人群患病率、临床相关性和种族差异。
影响因子：
5.6
作者：
H. Scofield;T. Roth;C. Drake
通讯作者：
C. Drake