Essential role of survivin, an inhibitor of apoptosis protein, in T cell development, maturation, and homeostasis.
Essential role of survivin, an inhibitor of apoptosis protein, in T cell development, maturation, and homeostasis.
复制标题
源凋亡蛋白抑制剂的基本作用在T细胞发育，成熟和稳态中。
DOI：
10.1084/jem.20031588
复制
发表时间：
2004-01-05
影响因子：
15.3
通讯作者：
Winoto, A
中科院分区：
文献类型：
--
作者：
Xing, Z;Conway, EM;Kang, CH;Winoto, A
存活素是一种凋亡抑制蛋白，也在有丝分裂过程中发挥作用。它在所有常见的肿瘤和具有增殖细胞的组织中表达，包括胸腺。为了研究其在细胞凋亡和增殖中的作用，我们产生了两个T细胞特异性生存素缺陷小鼠系，其缺失发生在不同的发育阶段。对早期缺失生存素小鼠的分析显示，在前T细胞受体增殖检查点处停滞。存活素在后期的丢失导致胸腺发育正常，但外周T细胞不成熟，数量显着减少。与体外研究相反，存活素的缺失不会导致细胞凋亡增加。然而，新生胸腺细胞的稳态和有丝分裂原诱导的生存素缺陷的T细胞的增殖大大受损。这些数据表明，生存素是T细胞凋亡不是必不可少的，但对T细胞的成熟和增殖是至关重要的，生存素介导的稳态扩张是T细胞发育的一个重要的生理过程。
Survivin is an inhibitor of apoptosis protein that also functions during mitosis. It is expressed in all common tumors and tissues with proliferating cells, including thymus. To examine its role in apoptosis and proliferation, we generated two T cell–specific survivin-deficient mouse lines with deletion occurring at different developmental stages. Analysis of early deleting survivin mice showed arrest at the pre–T cell receptor proliferating checkpoint. Loss of survivin at a later stage resulted in normal thymic development, but peripheral T cells were immature and significantly reduced in number. In contrast to in vitro studies, loss of survivin does not lead to increased apoptosis. However, newborn thymocyte homeostatic and mitogen-induced proliferation of survivin-deficient T cells were greatly impaired. These data suggest that survivin is not essential for T cell apoptosis but is crucial for T cell maturation and proliferation, and survivin-mediated homeostatic expansion is an important physiological process of T cell development.
登录
查看更多内容
影响因子：
64.5
作者：
Du, CY;Fang, M;Wang, XD
通讯作者：
Wang, XD
DOI：
10.1084/jem.182.4.961
发表时间：
1995-10-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ernst B;Surh CD;Sprent J
通讯作者：
Sprent J
影响因子：
9.2
作者：
Fraser, AG;James, C;Hengartner, MO
通讯作者：
Hengartner, MO
影响因子：
10.5
作者：
Hoffman, ES;Passoni, L;Hayday, AC
通讯作者：
Hayday, AC
DOI：
10.1073/pnas.111158698
发表时间：
2001-05-22
影响因子：
11.1
作者：
Kabra, NH;Kang, CH;Winoto, A
通讯作者：
Winoto, A