Selection for biparental inheritance of mitochondria under hybridization and mitonuclear fitness interactions.

Selection for biparental inheritance of mitochondria under hybridization and mitonuclear fitness interactions.
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DOI:
10.1098/rspb.2021.1600
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发表时间:
2021-12-08
期刊:
Proceedings. Biological sciences
影响因子:
--
通讯作者:
Dowling DK
Dowling DK
中科院分区:
其他
文献类型:
--
作者:
Allison TM;Radzvilavicius AL;Dowling DK

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在大多数真核生物中,线粒体的单亲遗传(UPI)优于双亲遗传(BPI)。然而,线粒体的BPI或父系泄漏的例子正变得越来越普遍。大多数报告的BPI病例发生在远亲亚群的杂交中。在这些情况下,BPI被认为是适应不良的;由女性或合子自噬机制识别不同男性线粒体DNA“标签”的失败引起。然而,最近的理论提出了BPI可以在适应性选择下进化的例子,并且在许多后生动物分类群中的实证研究已经证明了杂交后代中的远系繁殖衰退归因于种群特异性线粒体和核基因型的破坏(线粒体错配)。基于这些发展,我们假设,BPI可能有利于选择在杂交种群时,健身是由线粒体的相互作用。我们测试这个想法使用一个确定性的,基于模拟的人口遗传模型,并证明BPI是赞成严格的UPI在中等水平的杂交种群的典型基因流。我们的模型表明,BPI可能是稳定的,而不是一个短暂的现象,在杂交种群。
Uniparental inheritance (UPI) of mitochondria predominates over biparental inheritance (BPI) in most eukaryotes. However, examples of BPI of mitochondria, or paternal leakage, are becoming increasingly prevalent. Most reported cases of BPI occur in hybrids of distantly related sub-populations. It is thought that BPI in these cases is maladaptive; caused by a failure of female or zygotic autophagy machinery to recognize divergent male-mitochondrial DNA ‘tags’. Yet recent theory has put forward examples in which BPI can evolve under adaptive selection, and empirical studies across numerous metazoan taxa have demonstrated outbreeding depression in hybrids attributable to disruption of population-specific mitochondrial and nuclear genotypes (mitonuclear mismatch). Based on these developments, we hypothesize that BPI may be favoured by selection in hybridizing populations when fitness is shaped by mitonuclear interactions. We test this idea using a deterministic, simulation-based population genetic model and demonstrate that BPI is favoured over strict UPI under moderate levels of gene flow typical of hybridizing populations. Our model suggests that BPI may be stable, rather than a transient phenomenon, in hybridizing populations.
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