Matricellular proteins in cardiac adaptation and disease.
Matricellular proteins in cardiac adaptation and disease.
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DOI：
10.1152/physrev.00008.2011
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发表时间：
2012-04
影响因子：
33.6
通讯作者：
Frangogiannis NG
中科院分区：
文献类型：
--
作者：
Frangogiannis NG
“基质细胞蛋白”一词描述了一类结构无关的细胞外大分子，与结构基质蛋白不同，它们在组织结构中不起主要作用，而是在损伤后诱导并调节细胞与细胞和细胞与基质的相互作用。当释放到基质中时，基质细胞蛋白与生长因子、细胞因子和其他生物活性效应器结合，并与细胞表面受体结合，传导信号级联反应。基质细胞蛋白在心脏损伤和重塑过程中表达上调，在炎症、修复、纤维化和血管生成途径的调控中发挥重要作用。血栓反应蛋白(TSP)-1、-2和-4、tenascin-C和-X、分泌酸性且富含半胱氨酸的蛋白（SPARC）、骨桥蛋白、骨膜蛋白和CCN家族成员（包括CCN1和CCN2/结缔组织生长因子）参与多种心脏病理生理状况，包括心肌梗死、心脏肥大和纤维化、衰老相关的心肌重塑、心肌炎、糖尿病性心肌病和瓣膜病。这篇综述讨论了基质细胞蛋白的性质和特征，并介绍了我们目前对它们在心脏适应和疾病中的作用的了解。了解基质细胞蛋白在心肌病理生理中的作用和鉴定其作用的功能域可能导致设计具有治疗心脏病患者潜力的肽。
The term “matricellular proteins” describes a family of structurally unrelated extracellular macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue architecture, but are induced following injury and modulate cell:cell and cell:matrix interactions. When released to the matrix, matricellular proteins associate with growth factors, cytokines and other bioactive effectors and bind to cell surface receptors transducing signaling cascades. Matricellular proteins are upregulated in the injured and remodeling heart and play an important role in regulation of inflammatory, reparative, fibrotic and angiogenic pathways. Thrombospondins (TSP)-1, -2 and -4, tenascin-C and –X, secreted protein acidic and rich in cysteine (SPARC), osteopontin, periostin and members of the CCN family (including CCN1 and CCN2/Connective Tissue Growth Factor) are involved in a variety of cardiac pathophysiologic conditions, including myocardial infarction, cardiac hypertrophy and fibrosis, aging-associated myocardial remodeling, myocarditis, diabetic cardiomyopathy and valvular disease. This review manuscript discusses the properties and characteristics of the matricellular proteins and presents our current knowledge on their role in cardiac adaptation and disease. Understanding the role of matricellular proteins in myocardial pathophysiology and identification of the functional domains responsible for their actions may lead to design of peptides with therapeutic potential for patients with heart disease.
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影响因子：
5
作者：
Ahmed, MS;Oie, E;Attramadal, H
通讯作者：
Attramadal, H
DOI：
10.1073/pnas.95.11.6355
发表时间：
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