A Systematic Review and Meta-Analysis of Retinal Microvascular Features in Alzheimer's Disease.
A Systematic Review and Meta-Analysis of Retinal Microvascular Features in Alzheimer's Disease.
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阿尔茨海默病视网膜微血管特征的系统回顾和荟萃分析。
DOI：
10.3389/fnagi.2021.683824
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发表时间：
2021
影响因子：
4.8
通讯作者：
Ling L
中科院分区：
文献类型：
--
作者：
Jin Q;Lei Y;Wang R;Wu H;Ji K;Ling L
目的：本荟萃分析的目的是使用光学相干断层扫描血管造影术（OCTA）研究阿尔茨海默病（AD）患者的视网膜微血管特征。研究方法：系统检索PubMed、科克伦图书馆、Embase和Web of Science数据库中比较AD受试者和对照者视网膜微血管特征的已发表文章。使用平均差（MD）和95%置信区间（CI）来评估连续变量。使用Review Manager Version（RevMan）5.30分析数据。结果：9项研究纳入荟萃分析。分析显示，AD患者通过OCTA测量的黄斑全表面浅表和深血管密度（VD）值显著低于对照组（分别为MD =-1.10，P < 0.0001; MD =-1.61，P = 0.0001）。AD患者的OCTA测量值也显著低于对照组（MD =-1.42，P = 0.001），而与对照组相比，AD患者的脑旁浅表VD值无显著差异（MD =-3.67，P = 0.19）。此外，AD患者的中心凹无血管区（FAZ）大于对照组（MD = 0.08，P = 0.07），但未达到统计学显著性。结论：本荟萃分析表明，AD患者黄斑全表面和黄斑旁血管密度降低。此外，我们的汇总数据显示，AD患者的FAZ更大。因此，OCTA可用作识别和监测AD患者的诊断工具。
Objective: The aim of this meta-analysis was to investigate retinal microvascular features in patients with Alzheimer's disease (AD) using optical coherence tomography angiography (OCTA). Methods: PubMed, Cochrane Library, Embase, and Web of Science databases were systematically searched for published articles comparing retinal microvascular characteristics in subjects with AD and controls. The mean difference (MD) with a 95% confidence interval (CI) was used to assess continuous variables. Review Manager Version (RevMan) 5.30, was employed to analyze the data. Results: Nine studies were included in the meta-analysis. The analysis revealed that the macular whole enface superficial and deep vessel density (VD) values measured by OCTA were significantly lower in patients with AD than in controls (MD = −1.10, P < 0.0001; MD = −1.61, P = 0.0001, respectively). The value measured by OCTA for parafoveal superficial VD in patients with AD was also remarkably lower than that in the control group (MD = −1.42, P = 0.001), whereas there was no significant difference in the value for parafoveal deep VD (MD = −3.67, P = 0.19), compared to the controls. In addition, the foveal avascular zone (FAZ) was larger in patients with AD than in the control group (MD = 0.08, P = 0.07), although it did not reach statistical significance. Conclusions: The present meta-analysis indicated that the macular whole enface and parafoveal vessel densities were reduced in patients with AD. Moreover, our pooled data revealed that FAZ is larger in patients with AD. Consequently, OCTA may be utilized as a diagnostic tool to identify and monitor patients with AD.
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影响因子：
168.9
作者：
Ballard, Clive;Gauthier, Serge;Jones, Emma
通讯作者：
Jones, Emma
影响因子：
4
作者：
Florek, Lisa;Tiepolt, Solveig;Barthel, Henryk
通讯作者：
Barthel, Henryk
影响因子：
16.6
作者：
Iturria-Medina Y;Sotero RC;Toussaint PJ;Mateos-Pérez JM;Evans AC;Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
影响因子：
3.7
作者：
Fujiwara A;Morizane Y;Hosokawa M;Kimura S;Shiode Y;Hirano M;Doi S;Toshima S;Takahashi K;Hosogi M;Shiraga F
通讯作者：
Shiraga F
影响因子：
14.5
作者：
Dorr, Adrienne;Sahota, Bhupinder;Stefanovic, Bojana
通讯作者：
Stefanovic, Bojana