Factors affecting foveal avascular zone in healthy eyes: An examination using swept-source optical coherence tomography angiography.
Factors affecting foveal avascular zone in healthy eyes: An examination using swept-source optical coherence tomography angiography.
复制标题
DOI：
10.1371/journal.pone.0188572
复制
发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Shiraga F
中科院分区：
文献类型：
--
作者：
Fujiwara A;Morizane Y;Hosokawa M;Kimura S;Shiode Y;Hirano M;Doi S;Toshima S;Takahashi K;Hosogi M;Shiraga F
目的：应用扫描源光学相干断层血管造影（OCTA）研究影响健康眼中央凹无血管区（FAZ）面积的因素。这项前瞻性横断面研究包括144只眼睛，144人（77名女性，67名男性），最佳矫正视力至少为20/20，无眼部疾病史。使用OCTA评估浅表FAZ面积。研究人员检查了年龄、性别、视网膜中央厚度（CRT）、视网膜血管密度、屈光不正和轴向长度，以确定与FAZ面积的关系。受试者平均年龄42.1±20.2岁（范围：10-79岁）。平均FAZ面积为0.32±0.11 mm2，平均视网膜血管密度为35.53±0.92%。以FAZ面积为因变量，以年龄、性别、CRT、视网膜血管密度、屈光不正、眼轴长度为自变量，进行多元回归分析。本分析结果表明，CRT和视网膜血管密度与我们样本的FAZ面积显著相关（P < 0.001, R2 = 0.425）。年龄、性别、屈光不正、眼轴长度与FAZ面积无显著相关，而CRT、视网膜血管密度与FAZ面积呈负相关（CRT: P < 0.001, R2 = 0.356；视网膜血管密度：P < 0.001, R2 = 0.189）。OCTA结果提示CRT和视网膜血管密度对健康眼FAZ面积有负向影响。
To examine factors affecting foveal avascular zone (FAZ) area in healthy eyes using swept-source optical coherence tomography angiography (OCTA). This prospective, cross-sectional study included 144 eyes of 144 individuals (77 women, 67 men) with a best corrected visual acuity of at least 20/20 and no history of ocular disorders. The area of the superficial FAZ was assessed using OCTA. Age, gender, central retinal thickness (CRT), retinal vascular density, refractive error, and axial length were examined to determine associations with FAZ area. The mean age of the subjects was 42.1 ± 20.2 years (range: 10–79 years). The mean FAZ area was 0.32 ± 0.11 mm2, while the mean retinal vascular density was 35.53 ± 0.92%. Multivariate regression analysis was performed using FAZ area as the dependent variable and age, gender, CRT, retinal vascular density, refractive error, and axial length as independent variables. The results of this analysis demonstrate that CRT and retinal vascular density were significantly associated with FAZ area in our sample (P < 0.001, R2 = 0.425). Age, gender, refractive error, and axial length were not significantly correlated with FAZ area, while CRT and retinal vascular density were negatively correlated with FAZ area (CRT: P < 0.001, R2 = 0.356; retinal vascular density: P < 0.001, R2 = 0.189). OCTA results suggest that CRT and retinal vascular density negatively affect FAZ area in healthy eyes.
登录
查看更多内容
影响因子：
1.8
作者：
McAllister, John T.;Dubis, Adam M.;Tait, Diane M.;Ostler, Shawn;Rha, Jungtae;Stepien, Kimberly E.;Summers, C. Gail;Carroll, Joseph
通讯作者：
Carroll, Joseph
影响因子：
4.2
作者：
Samara, Wasim A.;Shahlaee, Abtin;Hsu, Jason
通讯作者：
Hsu, Jason
影响因子：
4.4
作者：
Adhi, Mehreen;Bonini Filho, Marco A.;Waheed, Nadia K.
通讯作者：
Waheed, Nadia K.
影响因子：
4.2
作者：
Lupidi, Marco;Coscas, Florence;Coscas, Gabriel
通讯作者：
Coscas, Gabriel
DOI：
10.1007/s00417-015-3143-7
发表时间：
2016-05-01
影响因子：
2.7
作者：
Di, Gong;Yu Weihong;Dong Fangtian
通讯作者：
Dong Fangtian