Transcriptomic plasticity of the hypothalamic osmoregulatory control centre of the Arabian dromedary camel.
Transcriptomic plasticity of the hypothalamic osmoregulatory control centre of the Arabian dromedary camel.
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DOI：
10.1038/s42003-022-03857-0
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发表时间：
2022-09-23
影响因子：
5.9
通讯作者：
中科院分区：
文献类型：
--
作者：
Water conservation is vital for life in the desert. The dromedary camel (Camelus dromedarius) produces low volumes of highly concentrated urine, more so when water is scarce, to conserve body water. Two hormones, arginine vasopressin and oxytocin, both produced in the supraoptic nucleus, the core hypothalamic osmoregulatory control centre, are vital for this adaptive process, but the mechanisms that enable the camel supraoptic nucleus to cope with osmotic stress are not known. To investigate the central control of water homeostasis in the camel, we first build three dimensional models of the camel supraoptic nucleus based on the expression of the vasopressin and oxytocin mRNAs in order to facilitate sampling. We then compare the transcriptomes of the supraoptic nucleus under control and water deprived conditions and identified genes that change in expression due to hyperosmotic stress. By comparing camel and rat datasets, we have identified common elements of the water deprivation transcriptomic response network, as well as elements, such as extracellular matrix remodelling and upregulation of angiotensinogen expression, that appear to be unique to the dromedary camel and that may be essential adaptations necessary for life in the desert. Comparative transcriptomic analyses between dromedary camels and rats provide insight into water homeostasis gene responses in animals under water stress conditions.
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影响因子：
2.6
作者：
Ali MA;Abu Damir H;Ali OM;Amir N;Tariq S;Greenwood MP;Lin P;Gillard B;Murphy D;Adem A
通讯作者：
Adem A
DOI：
10.1079/pavsnnr201712041
发表时间：
2017-01-01
期刊：
CAB Reviews
影响因子：
--
作者：
Abu Damir, H.;Ali, M. A.;Khalafalla, A. E.
通讯作者：
Khalafalla, A. E.
影响因子：
64.8
作者：
Calfon, M;Zeng, HQ;Ron, D
通讯作者：
Ron, D
影响因子：
5.9
作者：
Alvira-Iraizoz F;Gillard BT;Lin P;Paterson A;Pauža AG;Ali MA;Alabsi AH;Burger PA;Hamadi N;Adem A;Murphy D;Greenwood MP
通讯作者：
Greenwood MP
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y