Hypoxia alters protein balance in muscle cells: any relation with initiation and development of muscle atrophy in COPD?

缺氧改变肌肉细胞中的蛋白质平衡：与慢性阻塞性肺病肌肉萎缩的发生和发展有关系吗？

• 批准号: 170631
• 负责人: Debigare Richard
• 金额: $ 16.46万
• 依托单位: Universit Laval
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-09-01 至 2011-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=170631&lang=en
• 关键词: Akt; Atrogin-1; Cell Culture; Copd; Hypoxia; Proteasome

Muscle wasting is a significant problem in chronic obstructive pulmonary disease (COPD) which is associated with important clinical issues such as decreased functional status, reduced quality of life and increased mortality rate. Although accumulating kno

肌肉萎缩是慢性阻塞性肺疾病（COPD）的一个重要问题，它与功能状态下降、生活质量下降和死亡率增加等重要临床问题有关。虽然积累知识