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Novel bifunctional antiandrogens that suppress oncogenic activation of the androgen receptor in castration-resistant prostate cancer

Novel bifunctional antiandrogens that suppress oncogenic activation of the androgen receptor in castration-resistant prostate cancer
新型双功能抗雄激素可抑制去势抵抗性前列腺癌中雄激素受体的致癌激活
批准号：
206036
负责人：
Wu Jian Hui
金额：
$11.64万
依托单位：
CIUSSS de Centre-Ouest-de-l'Ile-de-Montral-Jewish General
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2010
资助国家：
加拿大
项目状态：
已结题
起止时间：
2010-03-01 至 2011-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=206036&lang=en
关键词：
Androgen Receptor Antiandrogen Castration-Resistant Prostate Cancer Ikk Mutation

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英文摘要
Over 30,000 men die from prostate cancer in Canada and USA each year. Prostate cancer cell growth is critically dependent on the androgen receptor (AR) signaling. Current mainstay treatment for early or advanced prostate cancer aims to suppress AR activat
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Development of novel pan-inhibitors of the androgen receptor variants as effective therapeutics for castration-resistant prostate cancer
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