A New Topical Antiandrogen Benefits Acne Treatment
A New Topical Antiandrogen Benefits Acne Treatment
批准号:
6831937
负责人:
CHARLES C-Y SHIH
金额:
$10.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2004
资助国家:
美国
项目状态:
已结题
起止时间:
2004-07-19 至 2006-03-31
中文摘要
描述(由申请人提供):
英文摘要
DESCRIPTION (provided by applicant):
Acne is the most common skin disorder encountered by physicians. It affects 80% of all persons between the ages of 11 and 30 years. Although the overall health is not impaired, acne can produce cutaneous and emotional scars that last a lifetime. Currently available therapies are mainly used to treat symptoms and are associated with severe drawbacks, such as skin irritation, requiring prolonged treatment, teratogenesis, and acquisition of antibiotic resistance. More effective or safer treatments are needed to achieve a better compliance in the patient. Androgens play a critical role in the development of acne, i.e., the cause of disease. In theory, use of androgen blockers (e.g. anti-androgens) would prevent or intervene in acne pathogenesis. Nevertheless, systemic anti-androgens cannot be used in men due to its potential side effect in male fertility. Even in women, systemic anti-androgens need to be prescribed in conjunction with oral contraceptives. Currently, there is no topical anti-androgen available, and search for an effective topical antiandrogen has been going on for the last two decades. Recently, we discovered a new class of anti-androgen, ASCJ4, which induces AR degradation and displaying a superior anti-androgen activity in vitro. Furthermore, we discovered that ASCJ4 after topically applied to fuzzy rats (a rodent model for human acne) attenuates seborrhea. In here, we propose to further study ASCJ4's potentiality as a topical drug candidate for acne. We will:
1. Perform acute dermal toxicity test to examine biosafety of ASCJ4 compound;
2. Study more fuzzy rats to confirm the sebaceous gland repressive efficacy of ASCJ4; and
3. Use another widely accepted rodent model for human acne, the hamster flank organs, to ensure the sebosuppressive effect of ASCJ4.
The derived information from this study will help define the ASCJ4's safety and efficacy and allow an evaluation as to whether ASCJ4 is developable as a topical anti-androgen drug for acne.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Development of an Oral Therapeutic Drug for Spinal and Bulbar Muscular Atrophy
-
批准号:8252177
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2011
-
负责人:CHARLES C-Y SHIH
-
依托单位:
Development of an Oral Therapeutic Drug for Spinal and Bulbar Muscular Atrophy
-
批准号:8041399
-
项目类别:
-
资助金额:$86.22万
-
财政年份:2011
-
负责人:CHARLES C-Y SHIH
-
依托单位:
Development of an Oral Therapeutic Drug for Spinal and Bulbar Muscular Atrophy
-
批准号:8723309
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2011
-
负责人:CHARLES C-Y SHIH
-
依托单位:
A New Topical Antiandrogen Benefits Acne Treatment
-
批准号:7274871
-
项目类别:
-
资助金额:$35.56万
-
财政年份:2004
-
负责人:CHARLES C-Y SHIH
-
依托单位:
A New Topical Antiandrogen Benefits Acne Treatment
-
批准号:7155625
-
项目类别:
-
资助金额:$44.6万
-
财政年份:2004
-
负责人:CHARLES C-Y SHIH
-
依托单位:
Anti-androgenic mechanism of a new compound
-
批准号:6550419
-
项目类别:
-
资助金额:$9.98万
-
财政年份:2002
-
负责人:CHARLES C-Y SHIH
-
依托单位:
Cell-Based High Throughput Screening for Anti-Androgens
-
批准号:6484915
-
项目类别:
-
资助金额:$10.0万
-
财政年份:2002
-
负责人:CHARLES C-Y SHIH
-
依托单位:
ANTI-ANDROGEN RECEPTOR MABS FOR HUMAN PROSTATE CANCER
-
批准号:3493269
-
项目类别:
-
资助金额:$5.0万
-
财政年份:1993
-
负责人:CHARLES C-Y SHIH
-
依托单位:
海外基金