Rac1 Signaling in Myocardial TNF-alpha Expression in Sepsis

脓毒症心肌 TNF-α 表达中的 Rac1 信号转导

• 批准号: 171780
• 负责人: Feng Qingping
• 金额: $ 51.47万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-09-01 至 2013-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=171780&lang=en
• 关键词: Lipopolysaccharide; Nitric Oxide; Sepsis; Signal Transduction; Tumor Necrosis Factor-Alpha

Sepsis is one of the main consequences of infectious diseases and occurs in 2-11% of all hospital or intensive care unit admissions. Mortality is 20-30% in sepsis and 40-80% in septic shock. Cardiac dysfunction is a common complication of septic shock. Li

脓毒症是传染病的主要后果之一，发生在所有住院或重症监护病房的2-11%。脓毒症的死亡率为20-30%，脓毒性休克的死亡率为40-80%。心功能不全是感染性休克的常见并发症。李