The Role of Rare and Somatic Variants in Ageing-Related Disease

罕见和体细胞变异在衰老相关疾病中的作用

基本信息

项目摘要

Osteoporosis is a common and costly ageing-related disease. Approximately one third to one half of women will experience an osteoporotic fracture in their lifetime and the cost of just hip fractures is expected to rise to $2.4 billion per year in Canada b
骨质疏松症是一种常见的和昂贵的衰老相关疾病。大约三分之一到一半的妇女在其一生中会经历髋部骨折,在加拿大,仅髋部骨折的费用预计将上升到每年24亿美元B

项目成果

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Richards Brent其他文献

Richards Brent的其他文献

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{{ truncateString('Richards Brent', 18)}}的其他基金

Artificial intelligence to create equitable multi-ethnic polygenic risk scores that improve clinical care
人工智能创建公平的多种族多基因风险评分,改善临床护理
  • 批准号:
    417900
  • 财政年份:
    2019
  • 资助金额:
    $ 20.4万
  • 项目类别:
    Operating Grants
Genetically Identified and Validated Biomarkers for Osteoporosis
骨质疏松症的基因鉴定和验证生物标志物
  • 批准号:
    390604
  • 财政年份:
    2018
  • 资助金额:
    $ 20.4万
  • 项目类别:
    Operating Grants
Causal Proteins for Osteoporosis
骨质疏松症的致病蛋白
  • 批准号:
    345698
  • 财政年份:
    2016
  • 资助金额:
    $ 20.4万
  • 项目类别:
    Operating Grants
MET-DETOX: Metabolic Consequences of Developmental Exposures to Toxins
MET-DETOX:发育过程中接触毒素的代谢后果
  • 批准号:
    328404
  • 财政年份:
    2015
  • 资助金额:
    $ 20.4万
  • 项目类别:
    Operating Grants
Mendelian randomization: Testing the causality of clinically-relevant biomarkers
孟德尔随机化:测试临床相关生物标志物的因果关系
  • 批准号:
    322736
  • 财政年份:
    2015
  • 资助金额:
    $ 20.4万
  • 项目类别:
    Operating Grants
Genomics of Osteoporosis and Vitamin D: From Correlations to Causation and Clinical Translation.
骨质疏松症和维生素 D 的基因组学:从相关性到因果关系和临床转化。
  • 批准号:
    333712
  • 财政年份:
    2015
  • 资助金额:
    $ 20.4万
  • 项目类别:
    Operating Grants
Pinpointing Causal Variants for Osteoporosis
查明骨质疏松症的致病变异
  • 批准号:
    268229
  • 财政年份:
    2012
  • 资助金额:
    $ 20.4万
  • 项目类别:
    Operating Grants
The Genetic Epidemiology of Osteoporotic Fractures; From Suceptibility Genes to Susceptible Populations
骨质疏松性骨折的遗传流行病学;
  • 批准号:
    171999
  • 财政年份:
    2008
  • 资助金额:
    $ 20.4万
  • 项目类别:
    Salary Programs
Genetic Epidemiology of Osteoporotic Fractures; From Susceptibility Genes to Susceptible Populations
骨质疏松性骨折的遗传流行病学;
  • 批准号:
    172829
  • 财政年份:
    2008
  • 资助金额:
    $ 20.4万
  • 项目类别:
    Operating Grants

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HIV-1帽表观遗传修饰
  • 批准号:
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炎症诱导分化中造血干细胞和祖细胞的表观遗传修饰
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炎症诱导分化中造血干细胞和祖细胞的表观遗传修饰
  • 批准号:
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    2022
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Targeted therapy of meningiomas: establishing the therapeutic role and molecular mechanisms of epigenetic modification in clinically aggressive meningiomas in vivo and in vitro
脑膜瘤的靶向治疗:建立表观遗传修饰在临床侵袭性脑膜瘤体内和体外的治疗作用和分子机制
  • 批准号:
    437192
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    2020
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Mechanistic basis of the role of Cbx3 in negatively regulating osteoclast differentiation through epigenetic modification
Cbx3通过表观遗传修饰负调节破骨细胞分化作用的机制基础
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    2019
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    Grant-in-Aid for Scientific Research (B)
Mechanistic basis of the role of Cbx3 in negatively regulating osteoclast differentiation through epigenetic modification
Cbx3通过表观遗传修饰负调节破骨细胞分化作用的机制基础
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细胞代谢通过表观遗传修饰调节调节性 T 细胞的分化
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