Finding new cellular factors of susceptibility/resistance to HIV-1 infection using a novel reporter virus and large-scale genomic/proteomic approaches

使用新型报告病毒和大规模基因组/蛋白质组学方法寻找 HIV-1 感染易感性/抵抗力的新细胞因子

• 批准号: 209564
• 负责人: Tremblay Michel J
• 金额: $ 44.38万
• 依托单位: Centre Hospitalier Universitaire de Qubec
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-09-01 至 2015-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=209564&lang=en
• 关键词: Aids; Gene Expression; Hiv-1; Microarray

Recent discoveries have shed some light on the mechanisms involved in the pathogenesis of HIV-1/AIDS. Among these, a significant relationship between the depletion by the virus of Th17 cells, which are responsible for the integrity of the intestinal mucos

最近的发现为 HIV-1/AIDS 的发病机制提供了一些线索。其中，Th17 细胞的病毒消耗与肠道粘膜完整性有显着关系。