Dissecting the mechanisms required to regulate cell division and growth downstream of the LKB1/AMPK tumour suppressor signalling pathway

剖析 LKB1/AMPK 肿瘤抑制信号通路下游调节细胞分裂和生长所需的机制

• 批准号: 217936
• 负责人: Peng Jimmy
• 金额: $ 10.93万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-10-01 至 2013-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=217936&lang=en
• 关键词: Ampk; Cancer; Lkb1; Model Organism; Notch; Peutz-Jegher Syndrome

Cancer is a disease that starts when our cells divide inappropriately, often because they have lost an essential "tumour suppressor" gene that normally keeps them from dividing. An example of a tumour suppressor is LKB1, a gene which is lost in patients w

癌症是一种疾病，当我们的细胞不适当地分裂时就会开始，通常是因为它们失去了一种基本的“肿瘤抑制”基因，这种基因通常会阻止它们分裂。肿瘤抑制基因的一个例子是LKB 1，这是一种在患有乳腺癌的患者中丢失的基因。