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HIV adaptation to immune selection pressures: historic trends and future implications

HIV adaptation to immune selection pressures: historic trends and future implications
HIV 对免疫选择压力的适应：历史趋势和未来影响
批准号：
230950
负责人：
Brumme Zabrina
金额：
$23.18万
依托单位：
Simon Fraser University (Burnaby, B.C.)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2011
资助国家：
加拿大
项目状态：
已结题
起止时间：
2011-03-01 至 2014-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=230950&lang=en
关键词：
Fitness Historic Specimens Hiv/Aids Immune Escape Phylogenetics Recombinant Virus Assays Replication Capacity Viral Evolution

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英文摘要
Despite HIV's enormous mutational capacity, analyses of contemporaneous HIV sequences have revealed that immune-driven HIV evolution, or "immune escape", occurs along generally reproducible pathways. However, the extent to which HIV has adapted to its hum
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