The International HIV Adaptation Collaborative: harnessing host and viral genetic data globally for HIV-1 vaccine design

国际艾滋病毒适应合作组织：利用全球宿主和病毒遗传数据进行 HIV-1 疫苗设计

• 批准号: 343054
• 负责人: Brumme Zabrina
• 金额: $ 52.91万
• 依托单位: Simon Fraser University (Burnaby, B.C.)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-03-01 至 2021-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=343054&lang=en
• 关键词: Ctl; Epitope; Eradication; Evolution; Genetic Diversity; Hiv; Hla; Immune Escape; Vaccine; Viral Fitness

Ending the HIV-1 pandemic will require effective vaccine(s). To date however, no HIV-1 vaccine candidate that has reached advanced clinical testing has been able to elicit protective cellular immune responses. Improved T-cell immunogen designs capable of

结束HIV-1大流行需要有效的疫苗。然而，迄今为止，还没有达到高级临床测试的HIV-1候选疫苗能够引起保护性细胞免疫应答。改进的T细胞免疫原设计，