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Mechanisms regulating persistent DNA damage signaling and the linked control of cell proliferation and extracellular signals

Mechanisms regulating persistent DNA damage signaling and the linked control of cell proliferation and extracellular signals
调节持续 DNA 损伤信号传导的机制以及细胞增殖和细胞外信号的关联控制
批准号：
227118
负责人：
Rodier Francis
金额：
$44.19万
依托单位：
Centre hospitalier de l'Universit de Montral (CHUM)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2011
资助国家：
加拿大
项目状态：
已结题
起止时间：
2011-03-01 至 2016-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=227118&lang=en
关键词：
Cell Cycle Checkpoints Cytokine Secretion Dna Damage Response Recovery Dna Damage Response Signaling Enzyme-Mediated Dna Breaks High-Content Imaging Medium-Throughput Measurements Persistent Dna Damage Signaling Primary Human Cell Culture Telomer

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Cells of the human body experience and fix DNA damage everyday, a process required to preserve health. This is illustrated in many human diseases, including cancer, which is often caused by errors during DNA repair. Additionally, intentional DNA damage in
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