Identification of broadly-neutralizing antibodies targeting HIV-1 envelope glycoproteins in their unbound conformation.

鉴定针对未结合构象的 HIV-1 包膜糖蛋白的广泛中和抗体。

• 批准号: 308033
• 负责人: Richard Jonathan
• 金额: $ 9.83万
• 依托单位: Centre hospitalier de l'Universit de Montral (CHUM)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-11-01 至 2016-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=308033&lang=en
• 关键词: B Cells; Broadly Neutralizing Antibodies; Envelope Glycoproteins; Hiv-1; Hiv-1 Vaccine

Prevention of HIV transmission requires approaches that interrupt the early phase of infection such as viral entry. This step of the viral cycle is mediated by the viral envelope glycoproteins (Env) which interact consecutively with the receptor CD4 and t

预防艾滋病毒传播需要采取措施，阻断感染的早期阶段，如病毒进入。病毒周期的这一步是由病毒包膜糖蛋白（Env）介导的，Env连续地与受体CD4和T细胞相互作用。