Multi-Omics Analysis of Broadly Neutralizing Antibodies and Therapeutic Vaccination

广泛中和抗体和治疗性疫苗的多组学分析

基本信息

  • 批准号:
    10724219
  • 负责人:
  • 金额:
    $ 141.27万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-07-11 至 2028-04-30
  • 项目状态:
    未结题

项目摘要

SUMMARY The goal of this P01 program is to define mechanisms of efficacy of broadly neutralizing antibodies (bNAbs) and therapeutic vaccines for HIV-1 in a highly collaborative and multifaceted research program. Our overall hypothesis is that immunologic strategies for HIV-1 cure delay viral rebound both by targeting the viral reservoir and by increasing host antiviral immunity. We will evaluate mechanisms of therapeutic efficacy in both humans and nonhuman primates (NHPs) using coordinated virologic, immunologic, and multi-omic approaches with the goal of developing improved next generation HIV-1 cure strategies. We will apply cutting- edge, high-throughput, multi-omic profiling platforms and integrate these data sets to generate a comprehensive tissue landscape and regulatory network of the viral reservoir and host immune responses. This program builds on our existing studies over the past several years in both humans and NHPs evaluating the ability of bNAbs and therapeutic vaccines to delay viral rebound following discontinuation of antiretroviral therapy (ART). We will first utilize existing samples from these studies to generate hypotheses regarding correlates of delayed viral rebound. We will then perform new interventional studies in NHPs with spatial multi- omic analyses in lymph nodes and gastrointestinal mucosal tissues to test hypotheses in order to define mechanisms of reservoir targeting by bNAbs and therapeutic vaccines. The significance of this program is the potential to define the biologic pathways that lead to delayed viral rebound following ART discontinuation. An improved understanding of partially effective bNAbs and therapeutic vaccines in humans and NHPs will lead to basic research advances that will allow the development of improved next generation HIV-1 cure approaches. To accomplish the goals of this P01 program, we propose the following Projects and Cores: Project 1. Multi-Omics Correlates of Broadly Neutralizing Antibody Efficacy Project 2. Multi-Omics Correlates of Therapeutic Vaccine Efficacy Core A. Administrative Core Core B. Multi-Omics Core Core C. Computational Analysis Core Core D. NHP Core
总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Dan H. Barouch其他文献

Pharmacokinetic interaction assessment of an HIV broadly neutralizing monoclonal antibody VRC07-523LS: a cross-protocol analysis of three phase 1 trials in people without HIV
  • DOI:
    10.1186/s12865-025-00687-7
  • 发表时间:
    2025-02-19
  • 期刊:
  • 影响因子:
    2.700
  • 作者:
    Tariro D. Chawana;Stephen R. Walsh;Lynda Stranix-Chibanda;Zvavahera M. Chirenje;Chenchen Yu;Lily Zhang;Kelly E. Seaton;Jack Heptinstall;Lu Zhang;Carmen A. Paez;Theresa Gamble;Shelly T. Karuna;Philip Andrew;Brett Hanscom;Magdalena E. Sobieszczyk;Srilatha Edupuganti;Cynthia L. Gay;Sharon B. Mannheimer;Christopher B. Hurt;Kathryn E. Stephenson;Laura L. Polakowski;Hans Spiegel;Margaret Yacovone;Stephanie Regenold;Catherine Yen;Jane AG. Baumblatt;Lucio Gama;Dan H. Barouch;Estelle Piwowar-Manning;Richard A. Koup;Georgia D. Tomaras;Ollivier Hyrien;Alison C. Roxby;Yunda Huang
  • 通讯作者:
    Yunda Huang
On-patient medical record and mRNA therapeutics using intradermal microneedles
住院病历与使用皮内微针的信使核糖核酸疗法
  • DOI:
    10.1038/s41563-024-02115-4
  • 发表时间:
    2025-02-24
  • 期刊:
  • 影响因子:
    38.500
  • 作者:
    Jooli Han;Maria Kanelli;Yang Liu;John L. Daristotle;Apurva Pardeshi;Timothy A. Forster;Ari Karchin;Brandon Folk;Lukas Murmann;Lisa H. Tostanoski;Sebastian E. Carrasco;Shahad K. Alsaiari;Erika Yan Wang;Khanh Tran;Linzixuan Zhang;Behnaz Eshaghi;Lauren Levy;Sydney Pyon;Charles Sloane;Stacey Qiaohui Lin;Alicia Lau;Collin F. Perkinson;Moungi G. Bawendi;Dan H. Barouch;Frédo Durand;Robert Langer;Ana Jaklenec
  • 通讯作者:
    Ana Jaklenec
Attenuated emMycobacterium tuberculosis/em vaccine protection in a low-dose murine challenge model
减毒鼠伤寒沙门菌疫苗在低剂量小鼠攻击模型中的保护作用
  • DOI:
    10.1016/j.isci.2023.106963
  • 发表时间:
    2023-06-16
  • 期刊:
  • 影响因子:
    4.100
  • 作者:
    Samuel J. Vidal;Daniel Sellers;Jingyou Yu;Shoko Wakabayashi;Jaimie Sixsmith;Malika Aid;Julia Barrett;Sage F. Stevens;Xiaowen Liu;Wenjun Li;Courtney R. Plumlee;Kevin B. Urdahl;Amanda J. Martinot;Dan H. Barouch
  • 通讯作者:
    Dan H. Barouch
SIV proviruses seeded later in infection are harbored in short-lived CD4sup+/sup T cells
在感染后期植入的猴免疫缺陷病毒(SIV)前病毒存在于短寿命的CD4<sup>+</sup>T细胞中
  • DOI:
    10.1016/j.celrep.2025.115663
  • 发表时间:
    2025-05-27
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Narmada Sambaturu;Emily J. Fray;Vivek Hariharan;Fengting Wu;Carolin Zitzmann;Francesco R. Simonetti;Dan H. Barouch;Janet D. Siliciano;Robert F. Siliciano;Ruy M. Ribeiro;Alan S. Perelson;Carmen Molina-París;Thomas Leitner
  • 通讯作者:
    Thomas Leitner
Nonhuman primate antigenic cartography of SARS-CoV-2
非人类灵长类动物对 SARS-CoV-2 的抗原图谱
  • DOI:
    10.1016/j.celrep.2024.115140
  • 发表时间:
    2025-01-28
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Annika Rössler;Antonia Netzl;Ninaad Lasrado;Jayeshbhai Chaudhari;Barbara Mühlemann;Samuel H. Wilks;Janine Kimpel;Derek J. Smith;Dan H. Barouch
  • 通讯作者:
    Dan H. Barouch

Dan H. Barouch的其他文献

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{{ truncateString('Dan H. Barouch', 18)}}的其他基金

NHP Core
NHP核心
  • 批准号:
    10724223
  • 财政年份:
    2023
  • 资助金额:
    $ 141.27万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10724220
  • 财政年份:
    2023
  • 资助金额:
    $ 141.27万
  • 项目类别:
Multi-Omics Correlates of Broadly Neutralizing Antibody Efficacy
广泛中和抗体功效的多组学关联
  • 批准号:
    10724224
  • 财政年份:
    2023
  • 资助金额:
    $ 141.27万
  • 项目类别:
CoVPN LOC Cross-Protocol Infrastructure Supplement for GY15 and GY16
适用于 GY15 和 GY16 的 CoVPN LOC 跨协议基础设施补充
  • 批准号:
    10571201
  • 财政年份:
    2022
  • 资助金额:
    $ 141.27万
  • 项目类别:
Project 2: Analysis of Reservoir Dynamics in SIV-Infected Rhesus Macaques
项目 2:感染 SIV 的恒河猴的储库动力学分析
  • 批准号:
    10599365
  • 财政年份:
    2022
  • 资助金额:
    $ 141.27万
  • 项目类别:
Project 2: Analysis of Reservoir Dynamics in SIV-Infected Rhesus Macaques
项目 2:感染 SIV 的恒河猴的储库动力学分析
  • 批准号:
    10459662
  • 财政年份:
    2022
  • 资助金额:
    $ 141.27万
  • 项目类别:
HIV Vaccines Clinical Trials Network Leadership and Operations Center
HIV 疫苗临床试验网络领导和运营中心
  • 批准号:
    10311601
  • 财政年份:
    2021
  • 资助金额:
    $ 141.27万
  • 项目类别:
I4C 2.0: Immunotherapy for Cure
I4C 2.0:免疫疗法治愈
  • 批准号:
    10469460
  • 财政年份:
    2021
  • 资助金额:
    $ 141.27万
  • 项目类别:
I4C 2.0: Immunotherapy for Cure
I4C 2.0:免疫疗法治愈
  • 批准号:
    10311894
  • 财政年份:
    2021
  • 资助金额:
    $ 141.27万
  • 项目类别:
CoVPN 3005 - Efficacy, Immunogenicity, and Safety of SARS-CoV-2 Recombinant Protein Vaccine with Adjuvant in Adults 18 Years of Age and Older
CoVPN 3005 - SARS-CoV-2 重组蛋白疫苗与佐剂对 18 岁及以上成人的功效、免疫原性和安全性
  • 批准号:
    10415762
  • 财政年份:
    2021
  • 资助金额:
    $ 141.27万
  • 项目类别:

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