New Surfaces for the Control of Endothelial Cell Function: Application in the Design of Biocompatible Stents

控制内皮细胞功能的新表面：在生物相容性支架设计中的应用

• 批准号: DP1094768
• 负责人: Prof Chiara Neto
• 金额: $ 18.81万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-08-12 至 2013-09-20
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1094768
• 关键词: New; Surfaces; Control; Endothelial; Cell

Using dewetting of thin polymer films, the present proposal will develop new structured biocompatible surfaces with controlled chemistry and topography, which will allow the growth of a normal (non-activated) monolayer of endothelial cells. Sophisticated molecular parameters will be used to assess that endothelial cells maintain their normal quiescent phenotype. The project sets the ground work for the design of improved, more biocompatible structured stents to minimise the abnormal growth of cells on and around the stent, thereby reducing the occurrence of vascular complications. Thus this research could improve the success rate of stents implanted into patients with cardiovascular disease and reduce health costs.

利用聚合物薄膜的脱湿，本提案将开发具有可控化学和地形的新型结构生物相容性表面，这将允许正常（非激活）单层内皮细胞的生长。复杂的分子参数将用于评估内皮细胞维持其正常的静态表型。该项目为设计改进的、更具生物相容性的支架结构奠定了基础，以最大限度地减少支架上和周围细胞的异常生长，从而减少血管并发症的发生。因此，本研究可以提高心血管疾病患者支架植入的成功率，降低医疗成本。