Comprehensive dissection of functional dependencies in a model protein network to reveal the mechanisms of robustness and fragility

全面剖析模型蛋白质网络中的功能依赖性，揭示稳健性和脆弱性机制

• 批准号: 368536
• 负责人: Landry Christian
• 金额: $ 76.63万
• 依托单位: Universit Laval
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-09-01 至 2022-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=368536&lang=en
• 关键词: Cell Biology; Genotype-Phenotype Maps; Model Systems; Protein Interaction Networks; Systems Biology

Every human is born with new mutations. Some of these mutations have devastating effects on newborns but most of these mutations have no effect on cell physiology, even if they slightly alter gene functions. This robustness to mutations is due to the arch

每个人出生时都有新的突变。其中一些突变对新生儿有毁灭性的影响，但大多数突变对细胞生理没有影响，即使它们轻微改变了基因功能。这种对突变的稳健性是由于弓