Approaches to regulate Cbl ubiquitin ligase activity and control oncogenic tyrosine kinase signaling.

调节 Cbl 泛素连接酶活性和控制致癌酪氨酸激酶信号传导的方法。

• 批准号: 401834
• 负责人: McGlade Catherine J
• 金额: $ 66.04万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-03-01 至 2024-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=401834&lang=en
• 关键词: Cancer; Cbl Ubiquitin Ligase; High Throughput Screen; Pediatric Leukemia; Signal Transduction; Slap Adaptor Protein; Tyrosine Kinase

Leukemia is the most common cancer in children and adolescents, accounting for about one out of three cancers in children. Recently, a protein Cbl has been found to have mutations in childhood leukemia. These mutations prevent Cbl from performing its fun

白血病是儿童和青少年中最常见的癌症，约占儿童癌症的三分之一。最近，一种蛋白质Cbl被发现在儿童白血病中有突变。 这些突变阻止了Cbl表演它的乐趣