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Elucidating the Impact of Allergen-Specific B Cell Frequency and Affinity on Allergic Reactivity Using Patient-Derived Antibody Sequences in Mouse Models of Peanut Allergy

Elucidating the Impact of Allergen-Specific B Cell Frequency and Affinity on Allergic Reactivity Using Patient-Derived Antibody Sequences in Mouse Models of Peanut Allergy
使用患者来源的抗体序列在花生过敏小鼠模型中阐明过敏原特异性 B 细胞频率和亲和力对过敏反应性的影响
批准号：
415420
负责人：
Wade-Vallance Adam
金额：
$7.65万
依托单位：
University of California (San Francisco)
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-10-01 至 2022-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=415420&lang=en
关键词：
Allergen-Specific B Cell Frequency Antibody Affinity B Cell Flow Cytometry Ige Peanut Allergy Plasma Cell

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英文摘要
Peanut allergy is becoming increasingly common in Canada with serious consequences for Canadians' health. When a person with peanut (PN) allergy ingests PN, they can experience a range of symptoms from discomfort to anaphylaxis, a potentially deadly form
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