Elucidating the Impact of Allergen-Specific B Cell Frequency and Affinity on Allergic Reactivity Using Patient-Derived Antibody Sequences in Mouse Models of Peanut Allergy

使用患者来源的抗体序列在花生过敏小鼠模型中阐明过敏原特异性 B 细胞频率和亲和力对过敏反应性的影响

• 批准号: 415420
• 负责人: Wade-Vallance Adam
• 金额: $ 7.65万
• 依托单位: University of California (San Francisco)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-10-01 至 2022-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=415420&lang=en
• 关键词: Allergen-Specific B Cell Frequency; Antibody Affinity; B Cell; Flow Cytometry; Ige; Peanut Allergy; Plasma Cell

Peanut allergy is becoming increasingly common in Canada with serious consequences for Canadians' health. When a person with peanut (PN) allergy ingests PN, they can experience a range of symptoms from discomfort to anaphylaxis, a potentially deadly form

花生过敏在加拿大变得越来越普遍，对加拿大人的健康造成严重后果。当患有花生 (PN) 过敏的人摄入 PN 时，他们可能会出现一系列症状，从不适到过敏反应（一种可能致命的形式）