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Inhibition of retroviral replication by the restriction factor TRIM5alpha, and its applications

Inhibition of retroviral replication by the restriction factor TRIM5alpha, and its applications
限制因子TRIM5α抑制逆转录病毒复制及其应用
批准号：
189010
负责人：
Berthoux Lionel
金额：
$35.31万
依托单位：
Universit du Qubec Trois-Rivières
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2009
资助国家：
加拿大
项目状态：
已结题
起止时间：
2009-09-01 至 2014-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=189010&lang=en
关键词：
Gene Therapy Genetic Screens Hiv-1 Innate Immunity Molecular Virology Retroviruses

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TRIM5alpha is a natural inhibitor of retroviruses, a family of viruses that includes HIV-1, the AIDS virus. Unfortunately, HIV-1 is not affected by the human version of TRIM5alpha, but it is efficiently inhibited by this protein in other primates. My labo
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