Study of the role of Myc-interacting zinc finger protein 1 on the transcriptional activity of the c-Myc proto-oncogene in B lymphocytes

Myc相互作用锌指蛋白1对B淋巴细胞c-Myc原癌基因转录活性的研究

• 批准号: 428832
• 负责人: Gabrielli Tabarez Lucia Paola
• 金额: $ 1.27万
• 依托单位: Universit de Montral
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-12-01 至 2020-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=428832&lang=en
• 关键词: B Lymphocytes; C-Myc; Lymphoblastic Leukemia And Lymphoma; Miz-1; Murine Model; Poz Domain (Poxvirus And Zinc Finger); Proto-Oncogene; Signalisation; Stability And Degradation Of Proteins; Transcription

"The c-Myc proto-oncogene is over-expressed in over 50% of human cancers and blocking its expression leads to tumor regression in animal models. An important partner of c-Myc is the BTB/POZ domain protein Miz-1. Our group has demonstrated that the express

“c-Myc原癌基因在超过50%的人类癌症中过度表达，阻断其表达会导致动物模型中的肿瘤消退。c-Myc的一个重要伴侣是BTB/POZ结构域蛋白Miz-1。我们的团队已经证明，