Understanding and modelling platelet flow and binding in blood

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Understanding and modelling platelet flow and binding in blood. This project aims to predict how platelets flow through vascular scale geometries, using an experimental and numerical development programme. Platelets maintain a healthy vascular system. Like other cells, they respond to local stimuli: the concentration of chemical agonists, bonds with neighbouring species, fluid dynamic stresses, and even their history. On a single cell level, many of these biophysical processes are not understood or quantified. At the blood vessel level, multiscale modelling techniques cannot translate this single cell knowledge to capture how collections of platelets behave. This project is expected to lead to better therapies for cardiovascular disease and a new class of strongly interacting multiphase fluid dynamics problems.