Understanding and modelling platelet flow and binding in blood

了解血液中的血小板流动和结合并对其进行建模

• 批准号: LP160100786
• 负责人: Dr Dalton Harvie
• 金额: $ 29.15万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-12-15 至 2021-12-15
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP160100786
• 关键词: Understanding; modelling; platelet; flow; binding

Understanding and modelling platelet flow and binding in blood. This project aims to predict how platelets flow through vascular scale geometries, using an experimental and numerical development programme. Platelets maintain a healthy vascular system. Like other cells, they respond to local stimuli: the concentration of chemical agonists, bonds with neighbouring species, fluid dynamic stresses, and even their history. On a single cell level, many of these biophysical processes are not understood or quantified. At the blood vessel level, multiscale modelling techniques cannot translate this single cell knowledge to capture how collections of platelets behave. This project is expected to lead to better therapies for cardiovascular disease and a new class of strongly interacting multiphase fluid dynamics problems.

了解和模拟血小板在血液中的流动和结合。这个项目旨在利用实验和数值开发程序来预测血小板如何通过血管尺度的几何形状流动。血小板维持一个健康的血管系统。像其他细胞一样，它们对局部刺激做出反应：化学激动剂的浓度、与邻近物种的结合、流体动态压力，甚至它们的历史。在单细胞水平上，这些生物物理过程中的许多都没有被理解或量化。在血管层面上，多尺度建模技术不能转化这种单细胞知识来捕捉血小板集合的行为。该项目有望为心血管疾病带来更好的治疗方法，并带来一类新的强相互作用的多相流体动力学问题。