A novel role for gangliosides in extracellular vesicle biogenesis and mHTT secretion

神经节苷脂在细胞外囊泡生物发生和 mHTT 分泌中的新作用

• 批准号: 466524
• 负责人: Ibanga Jeremies U
• 金额: $ 1.27万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-12-01 至 2022-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=466524&lang=en
• 关键词: Extracellular Vesicles; Gangliosides; Huntington'S Disease; Neurodegeneration; Neuroprotection; Proteastasis

Huntington's disease (HD) is a genetic disorder caused by a mutation in the Huntingtin gene that results in the formation and accumulation of the toxic mutant Huntingtin protein (mHTT). Abundance of mHTT causes accretion of neuronal death in the brain, in

亨廷顿氏病（HD）是一种由亨廷顿基因突变引起的遗传性疾病，导致有毒突变亨廷顿蛋白（mHTT）的形成和积累。mHTT的丰富会导致大脑中神经元死亡的增加