The role of gangliosides in the secretion and clearance of mutant huntingtin through extracellular vesicles.

神经节苷脂在通过细胞外囊泡分泌和清除突变亨廷顿蛋白中的作用。

• 批准号: 458196
• 负责人: Monyror John G
• 金额: $ 7.65万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-11-01 至 2024-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=458196&lang=en
• 关键词: Extracellular Vesicles; Gangliosides; Huntington'S Disease; Microglia

Huntington's disease (HD) is a hereditary and currently incurable neurodegenerative disease that is caused by accumulation of a toxic protein called mutant huntingtin in neurons. Gangliosides are lipids that are abundant in the healthy brain and are impor

亨廷顿病 (HD) 是一种遗传性且目前无法治愈的神经退行性疾病，由神经元中一种称为突变亨廷顿蛋白的有毒蛋白质积累引起。神经节苷脂是健康大脑中丰富的脂质，对健康大脑至关重要