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HMGB1 as a Key Driver of B Cell Hyperactivity in the Pathogenesis of Systemic Sclerosis Associated Pulmonary Arterial Hypertension

HMGB1 as a Key Driver of B Cell Hyperactivity in the Pathogenesis of Systemic Sclerosis Associated Pulmonary Arterial Hypertension
HMGB1 作为 B 细胞过度活跃在系统性硬化症相关肺动脉高压发病机制中的关键驱动因素
批准号：
466768
负责人：
Sulstarova Sonja
金额：
$1.27万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2021
资助国家：
加拿大
项目状态：
已结题
起止时间：
2021-12-01 至 2022-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=466768&lang=en
关键词：
Autoimmunity B Cell Hyperactivity Hmgb1 Lung Physiology Perivascular Inflammation Pulmonary Arterial Hypertension Systemic Sclerosis

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Pulmonary Hypertension (PH) is a progressively fatal disease defined by a resting mean pulmonary arterial pressure of 20 mmHg. A subset of PH, known as pulmonary arterial hypertension (PAH) is localized to the lung vasculature and is characterized by peri
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