HMGB1 as a Key Driver of B Cell Hyperactivity in the Pathogenesis of Systemic Sclerosis Associated Pulmonary Arterial Hypertension

HMGB1 作为 B 细胞过度活跃在系统性硬化症相关肺动脉高压发病机制中的关键驱动因素

• 批准号: 466768
• 负责人: Sulstarova Sonja
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-12-01 至 2022-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=466768&lang=en
• 关键词: Autoimmunity; B Cell Hyperactivity; Hmgb1; Lung Physiology; Perivascular Inflammation; Pulmonary Arterial Hypertension; Systemic Sclerosis

Pulmonary Hypertension (PH) is a progressively fatal disease defined by a resting mean pulmonary arterial pressure of 20 mmHg. A subset of PH, known as pulmonary arterial hypertension (PAH) is localized to the lung vasculature and is characterized by peri

肺动脉高压（PH）是一种进行性致死性疾病，定义为静息平均肺动脉压20 mmHg。PH的一个子集，称为肺动脉高压（PAH），局限于肺血管系统，其特征是肺动脉高压（PAH）。