Defining the molecular mechanisms that direct Heat Shock Proteins to neuronal projections in response to proteotoxic damage

定义将热休克蛋白引导至神经元投射以响应蛋白毒性损伤的分子机制

• 批准号: 468536
• 负责人: Vera Ugalde Maria
• 金额: $ 56.29万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-09-01 至 2027-09-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=468536&lang=en
• 关键词: Heat Shock Proteins; Local Protein Synthesis; Mrna; Neuronal Proteostasis; Rna Binding Proteins; Subcellular Trafficking

Increased lifespan in developed countries has led to a higher prevalence of diverse age-related neurodegenerative disorders. They are known as "protein conformational diseases" because the common cause of the neuronal malfunction is the toxic deposit of m

发达国家寿命的延长导致各种年龄相关神经退行性疾病的患病率更高。它们被称为“蛋白质构象疾病”，因为神经元功能障碍的常见原因是蛋白质的毒性存款。