Unequal protein damage partitioning during asymmetric stem cell division determines the differential lifespan of progeny

不对称干细胞分裂过程中不均匀的蛋白质损伤分配决定了后代的不同寿命

• 批准号: 197432
• 负责人: Bufalino Mary R
• 金额: $ 7.29万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-11-01 至 2011-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=197432&lang=en
• 关键词: Female Germline Stem Cell; Intestinal Stem Cell; Lifespan; Neural Stem Cell; Neuroblast; Reactive Oxygen Species; Stem Cell

Stem cells divide asymmetrically to self-renew and produce a differentiated cell, for example a skin cell. Although stem cells can survive throughout the life of the organism they are also susceptible to causes of aging, such as the build up of damaged pr

干细胞不对称分裂以自我更新并产生分化细胞，例如皮肤细胞。虽然干细胞可以在生物体的整个生命过程中存活，但它们也容易受到衰老原因的影响，例如受损细胞的积累。