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Facilitating the Development of New Therapeutics for Diabetes, Pre-Diabetes and Obesity by Inhibition of Human Pancreatic Alpha-Amylase: A Structural and Mechanistic Approach

Facilitating the Development of New Therapeutics for Diabetes, Pre-Diabetes and Obesity by Inhibition of Human Pancreatic Alpha-Amylase: A Structural and Mechanistic Approach
通过抑制人胰腺α-淀粉酶促进糖尿病、糖尿病前期和肥胖症新疗法的开发：一种结构和机制方法
批准号：
212478
负责人：
Brayer Gary D
金额：
$55.83万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2010
资助国家：
加拿大
项目状态：
已结题
起止时间：
2010-09-01 至 2015-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=212478&lang=en
关键词：
Diabetes Enzyme Kinetics Inhibitor Design And Optimization Inhibitor Identification And Characterization Mechanism Based Inhibitor Synthesis Mechanistic Studies Of Enzymatic Catalysis Obesity Protein Structure - Function Relationships Proteomic Ap

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Diabetes and obesity are serious chronic diseases that lead to significantly reduced life expectancy and associated life-threatening complications such as heart disease, stroke, blindness, kidney failure and lower limb amputation. The incidence of diabete
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