Drug design principles for nicotinic acetylcholine receptor-channels

烟碱乙酰胆碱受体通道的药物设计原则

• 批准号: 214708
• 负责人: Bruhova Iva
• 金额: $ 10.93万
• 依托单位: State University of New York (Buffalo)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-10-01 至 2013-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=214708&lang=en
• 关键词: Acetylcholine Receptor; Channel Gating; Drug Binding; Drug Design; Kinetic Analysis; Ligand-Receptor Interactions; Molecular Modelling; Monte Carlo-Energy Minimization; Protein Engineering; Single-Channel Electrophysiology

Synapses are the primary points of communications in the nervous system. Nicotinic acetylcholine receptor-channels (AChRs) are involved in the fast transmission of signals at nerve-nerve and nerve-muscle synapses. Small molecules, called agonists, bind to

突触是神经系统中的主要通讯点。烟碱型乙酰胆碱受体通道（AChRs）参与神经-神经和神经-肌肉突触的快速信号传递。小分子，称为激动剂，