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Thiopurine S-methyltransferase testing for averting drug toxicity in pediatric patients receiving thiopurines: An application of enhanced meta-analysis of diagnostic tests

Thiopurine S-methyltransferase testing for averting drug toxicity in pediatric patients receiving thiopurines: An application of enhanced meta-analysis of diagnostic tests
硫嘌呤 S-甲基转移酶测试可避免接受硫嘌呤治疗的儿科患者的药物毒性：诊断测试增强荟萃分析的应用
批准号：
285225
负责人：
Ungar Wendy J
金额：
$7.22万
依托单位：
Hospital for Sick Children (Toronto)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2013
资助国家：
加拿大
项目状态：
已结题
起止时间：
2013-04-01 至 2014-04-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=285225&lang=en
关键词：
Acute Lymphoblastic Leukemia Cost-Effectiveness Analysis Diagnostic Testing Inflammatory Bowel Disease Meta-Analysis Pharmacogenetic Testing Sensitivity And Specificity Systematic Review Thiopurine S-Methyltransferase Thiopurines

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英文摘要
Thiopurine drugs are used to treat children with severe chronic diseases, such as leukemia and inflammatory bowel disease. Approximately 11 percent of the population have an alteration in their genes that causes a defect in the enzyme TPMT which does not
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