Pulsatile Flow and the Susceptibility of Arteries to Atherosclerosis

脉动血流和动脉对动脉粥样硬化的易感性

• 批准号: 8416361
• 负责人: Christopher Zarins
• 金额: $ 34.9万
• 依托单位: University of Chicago
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 1989-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8416361&HistoricalAwards=false
• 关键词: Pulsatile; Flow; Susceptibility; Arteries; Atherosclerosis

The goal of this project is to determine the role of unsteady fluid dynamics in the initiation, progression, complication and possible regression of atherosclerotic plaques. Research will focus on unsteady flow and early atherosclerotic lesions in three situations: the human carotid bifurcation, the descending thoracic aorta of monkeys, and the human abdominal aorta. Fluid dynamics research will concentrate upon unsteady flows in three-dimensional geometries, the evolution of coherent and random flow disturbances during pulsatile flows, and unsteady separation. Biological research will investigate the quantitative distribution of early atherosclerotic lesions, the alignment of endothelial cells in bifurcating vessels, and the relation between plaque composition and wall structure.

这个项目的目标是确定不稳定流体的作用 在发病、进展、并发症和可能的 动脉粥样硬化斑块的消退。 研究将集中在不稳定的 血流和早期动脉粥样硬化病变在三种情况下：人类 颈动脉分叉，猴的降胸主动脉，以及 人体腹主动脉 流体动力学研究将集中在 三维几何形状的非定常流， 脉动流期间的相干和随机流扰动，以及 非定常分离 生物学研究将调查 早期动脉粥样硬化病变的定量分布， 分叉血管内皮细胞的排列， 牙菌斑成分和牙壁结构之间的关系。