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Assessing the efficacy of novel synthetic Wnt ligands to promote endothelial cell barrier function in diseases.

Assessing the efficacy of novel synthetic Wnt ligands to promote endothelial cell barrier function in diseases.
评估新型合成 Wnt 配体促进疾病中内皮细胞屏障功能的功效。
批准号:
434137
负责人:
Angers Stephane
金额:
$61.3万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2020
资助国家:
加拿大
项目状态:
未结题
起止时间:
2020-10-01 至 2025-10-01

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中文摘要
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英文摘要
One of the most important class of molecules involved in embryonic development and adult tissue homeostasis are the Wnt family of secreted proteins. In humans, 19 Wnt proteins activate 10 cell surface Frizzled receptors. We have developed antibodies that
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Targeting Glioblastoma Heterogeneity through identification of subtype-specific genetic vulnerabilities
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    409658
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    Operating Grants
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    $59.63万
  • 财政年份:
    2019
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Identification of GBM genetic wiring vulnerabilities.
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    341710
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    2016
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Pharmacological and biochemical basis of ligand-biased signalling at the Smoothened receptor.
  • 批准号:
    333012
  • 项目类别:
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  • 资助金额:
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  • 财政年份:
    2015
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Wnt signalling circuitries in development and cancer.
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    253421
  • 项目类别:
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  • 负责人:
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海外基金