Venom-derived blood-brain-barrier shuttles

毒液衍生的血脑屏障穿梭机

• 批准号: DP230102707
• 负责人: A/Prof Markus Muttenthaler
• 金额: $ 36.2万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-02-20 至 2026-02-19
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102707
• 关键词: Venom; derived; blood; brain; barrier

This project aims to discover new venom peptides capable of crossing the blood-brain barrier and to develop non-toxic peptide-based brain delivery systems. It addresses long-standing challenges and knowledge gaps in the delivery of macromolecules across biological barriers. Expected outcomes include an improved understanding of the strategies nature exploits to reach targets in the brain, mechanistic pathways to cross biological membranes, and innovative discovery and chemistry strategies to advance fundamental research across the chemical and biological sciences. Anticipated benefits include technological innovations relevant to Australia’s biotechnology sector and enhanced capacity for cross-disciplinary collaboration.

该项目旨在发现能够穿过血脑屏障的新型毒液肽，并开发无毒的基于肽的脑递送系统。它解决了在跨越生物屏障递送大分子方面的长期挑战和知识空白。预期成果包括更好地理解大自然用来达到大脑目标的策略，穿过生物膜的机械途径，以及创新的发现和化学策略，以推进化学和生物科学的基础研究。预期的好处包括与澳大利亚生物技术部门有关的技术创新和加强跨学科合作的能力。