Molecular and physiological consequences of the diabetes-related PGC-1a Gly482Ser polymorphism.

糖尿病相关 PGC-1a Gly482Ser 多态性的分子和生理后果。

• 批准号: 476199
• 负责人: Galipeau Maria
• 金额: $ 7.65万
• 依托单位: Institut de recherches cliniques de Montral
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-11-01 至 2025-11-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=476199&lang=en
• 关键词: Energy Metabolism; Gene Regulation And Expression; Induced Pluripotent Stem Cells; Mass Spectrometry; Mitochondrial Biogenesis; Obesity; Post-Translational Modifications; Proteasomal Degradation; Single Nucleotide Polymorphism; Type 2 Diabetes

Blood sugar levels can rise after a meal. To control blood sugar levels, the pancreas releases the hormone insulin. Insulin converts sugar from food into energy for our cells. In people with type 2 diabetes, certain tissues become unresponsive to insulin,

餐后血糖水平可能会上升。为了控制血糖水平，胰腺会释放胰岛素。胰岛素将食物中的糖转化为细胞的能量。在2型糖尿病患者中，某些组织对胰岛素无反应，