Determining the mechanisms of toxicity of misfolded SOD1 on mitochondria

确定错误折叠的 SOD1 对线粒体的毒性机制

• 批准号: 195731
• 负责人: Pickles Sarah Rose M
• 金额: --
• 依托单位: Universit de Montral
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-10-01 至 2012-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=195731&lang=en
• 关键词: Amyotrophic Lateral Sclerosis; Calcium Buffering; Flow Cytometry; Mitochondria; Mitochondrial Transmembrane Potential; Neurodegeration; Superoxide Dismutase

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized by the loss of upper and lower motor neurons in the brain and spinal cord. Onset occurs between 45 and 60 years with a quick disease progression. At present, there is no cur

肌萎缩侧索硬化症（ALS）是一种神经退行性疾病，其特征在于大脑和脊髓中的上运动神经元和下运动神经元的丧失。发病年龄在45至60岁之间，疾病进展迅速。目前，