Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking

基于泛素的新型 Galphas 调节对受体信号传导和运输的影响

• 批准号: 489527
• 负责人: Lavoie Christine
• 金额: $ 73.56万
• 依托单位: Universit de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-09-01 至 2028-09-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=489527&lang=en
• 关键词: Endosomal Sorting; G Alpha S; G Protein Coupled Receptor (Gpcr); Heart-Cardiomyocytes; Heterotrimeric G Proteins; Intracellular Trafficking; Signal Transduction; Ubiquitin; Ubiquitin Interacting Motif (Uim)

The Galphas (Gas) subunit is classically known to act as a molecular switch that relays extracellular signals from G protein-coupled receptors (GPCRs) located on plasma membranes to downstream effectors. Gas has been studied for more than thirty years and

Galphas （Gas）亚基通常被认为是一个分子开关，将位于质膜上的G蛋白偶联受体（gpcr）的细胞外信号传递给下游效应器。天然气已经被研究了三十多年