Dissecting the roles of DNA-binding autoinhibition, post-translational modification and protein partnerships in the regulation of the transcription factor ETV6 (or TEL)

剖析 DNA 结合自抑制、翻译后修饰和蛋白质伙伴关系在转录因子 ETV6（或 TEL）调节中的作用

• 批准号: 300387
• 负责人: De Soumya
• 金额: $ 6.01万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-11-01 至 2015-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=300387&lang=en
• 关键词: Autoinhibition; Biomolecular Structure; Drug Design; Isothermal Titration Calorimetry (Itc); Leukemia; Nmr Spectroscopy; Protein Dynamics; Protein-Dna Interaction; Transcription Factors; X-Ray Crystallography

Leukemia is a type of cancer that affects blood and bone marrow. The protein ETV6 has been widely implicated in various forms of leukemia and is an important therapeutic target. ETV6 is a transcription factor that plays key roles in the formation of blood

白血病是一种影响血液和骨髓的癌症。ETV6蛋白广泛参与各种形式的白血病，是一个重要的治疗靶点。ETV6是一种在血液形成中起关键作用的转录因子