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Genome-wide Characterization of Liver Pregnane X Receptor Binding Sites and their Role in Interindividual Drug Response

Genome-wide Characterization of Liver Pregnane X Receptor Binding Sites and their Role in Interindividual Drug Response
肝脏孕烷 X 受体结合位点的全基因组特征及其在个体间药物反应中的作用
批准号：
194074
负责人：
Smith Robin P
金额：
$3.64万
依托单位：
University of California (San Francisco)
依托单位国家：
加拿大
项目类别：
Fellowship Programs
财政年份：
2009
资助国家：
加拿大
项目状态：
已结题
起止时间：
2009-10-01 至 2011-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=194074&lang=en
关键词：
Adverse Drug Reactions Chromatin Immunoprecipitation Cytochrome P450 Drug Metabolizing Enzymes Drug Transporters Gene Regulatory Sequences Human Nucleotide Variation Next-Generation Sequencing Pregnane X Receptor Tail Vein Injections

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Adverse reactions to drug treatments constitute a substantial health problem that is estimated to be the fifth leading cause of death globally. Interindividual genetic differences have been shown to play an important causative role in these reactions. One
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