Overcoming inactivation of oncolytic reovirus by proteases in breast tumor microenvironments.

克服乳腺肿瘤微环境中蛋白酶对溶瘤呼肠孤病毒的灭活。

• 批准号: 453388
• 负责人: Shmulevitz Maya
• 金额: $ 4.37万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-03-01 至 2023-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=453388&lang=en
• 关键词: Immunotherapy; Oncolytic Viruses &Amp

BACKGROUND: Reovirus (T3wt) is in phase 3 clinical trials for treatment of breast and other cancers. My laboratory seeks to further adapt reovirus towards breast tumor cells and environments, with hopes to improve the potency of reovirus therapy. Using ex

背景：呼肠孤病毒（T3wt）正在进行治疗乳腺癌和其他癌症的3期临床试验。我的实验室寻求进一步使呼肠孤病毒适应乳腺肿瘤细胞和环境，希望提高呼肠孤病毒治疗的效力。使用离