Understanding and exploiting post-entry steps of oncolytic reovirus replication and assembly

了解和利用溶瘤呼肠孤病毒复制和组装的进入后步骤

• 批准号: 379464
• 负责人: Shmulevitz Maya
• 金额: $ 57.4万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-03-01 至 2023-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=379464&lang=en
• 关键词: Enteric Viruses; Reovirus/Reoviridae; Viral Oncolysis; Virulence; Virus Assembly; Virus Factories; Virus Fitness; Virus Niche Of Infection; Virus Proteins; Virus Replication

Reovirus is a harmless virus, it spreads among humans and some animals through the intestine without causing disease. Reovirus has also been demonstrated to help treat tumors in animal models and is being tested in clinical human trials as a cancer therap

呼肠孤病毒是一种无害的病毒，它通过肠道在人类和一些动物中传播，不会引起疾病。呼肠孤病毒也已被证明有助于治疗动物模型中的肿瘤，并正在临床人体试验中作为癌症治疗方法进行测试。