Anaerobic Biodegradation of Hazardous Phenols and Its Effecton Genotoxicity

有害酚类的厌氧生物降解及其对遗传毒性的影响

• 批准号: 8605143
• 负责人: Lily Young
• 金额: --
• 依托单位: New York University Medical Center
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1989-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8605143&HistoricalAwards=false
• 关键词: Anaerobic; Biodegradation; Hazardous; Phenols; Its

Support is provided for research on the mechanisms by which phenolic substances are degraded by anaerobic microorganisms. This research is specifically directed at chlorinated phenols, nitrophenols, and methylphenols which are produced synthetically or which may be an intermediate decomposition product of more complex organic substances. Metabolism of these compounds under methanogenic and nitrate reducing conditions will be characterized as to the rate, extent, and major metabolites of degradation. In addition, their genotoxicity and any changes in genotoxicity as a result of anaerobic metabolism will ber determined. Completion of the work will elucidate the differences or similarities in the anaerobic metabolic pathways of the compound under the two reducing conditions and relate them to genotoxicity.

为厌氧微生物降解酚类物质的机理研究提供了支持。本研究专门针对氯代苯酚、硝基苯酚和甲基苯酚，它们是合成的，也可能是更复杂的有机物质的中间分解产物。这些化合物在产甲烷和硝酸盐还原条件下的代谢将以降解的速率、程度和主要代谢物为特征。此外，还将确定它们的遗传毒性以及由于无氧代谢而引起的遗传毒性变化。这项工作的完成将阐明在两种还原条件下化合物厌氧代谢途径的差异或相似之处，并将其与遗传毒性联系起来。