Thermodynamic Phase Equilibrium Properties of Partially Mis-cible Binary Solvent Mixtures in the Vicinity of the Immis- cibility Critical Point (Expedited Award for Novel Research)

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The purpose of this project is to find a new class of solvents with similar thermodynamic properties to those of fluids at their gas-liquid critical point. The goal of the present effort is to confirm the theoretical predictions that binary mixtures have enhanced selectivity for dissolving various compounds. Supercritical extraction processes are receiving wide interest; however, the number of liquids which have critical points at both low temperatures and pressures is limited. It is intended to use Thin Layer Chromatographic plates (TLC) as the stationary phase and to use various immiscible solvent mixtures showing a CST point as a mobile phase. The difference in the rates of mobility of various compounds, near and far away from the CST point, will be used as a measure of solubility. It is especially intended to check if binary mixtures of optically active compounds have enhanced selectivity near the CST for the components of a racemic mixture.