Thermodynamic Phase Equilibrium Properties of Partially Mis-cible Binary Solvent Mixtures in the Vicinity of the Immis- cibility Critical Point (Expedited Award for Novel Research)

本项目的目的是寻找一类新的溶剂，其热力学性质与流体在气液临界点的热力学性质相似。目前工作的目标是证实理论预测，即二元混合物提高了溶解各种化合物的选择性。超临界萃取过程正受到广泛的关注；然而，在低温和压力下具有临界点的液体数量有限。它的目的是使用薄层色谱板(TLC)作为固定相，并使用显示CST点的各种不相容的溶剂混合物作为流动相。各种化合物在靠近和远离CST点时的迁移率的差异将被用作溶解度的衡量标准。它特别用于检查光学活性化合物的二元混合物是否提高了外消旋混合物组分在CST附近的选择性。

The purpose of this project is to find a new class of solvents with similar thermodynamic properties to those of fluids at their gas-liquid critical point. The goal of the present effort is to confirm the theoretical predictions that binary mixtures have enhanced selectivity for dissolving various compounds. Supercritical extraction processes are receiving wide interest; however, the number of liquids which have critical points at both low temperatures and pressures is limited. It is intended to use Thin Layer Chromatographic plates (TLC) as the stationary phase and to use various immiscible solvent mixtures showing a CST point as a mobile phase. The difference in the rates of mobility of various compounds, near and far away from the CST point, will be used as a measure of solubility. It is especially intended to check if binary mixtures of optically active compounds have enhanced selectivity near the CST for the components of a racemic mixture.