EXAFS Investigation of Metalloproteins

金属蛋白的 EXAFS 研究

• 批准号: 8613948
• 负责人: Edward Stern
• 金额: $ 25.79万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8613948&HistoricalAwards=false
• 关键词: EXAFS; Investigation; Metalloproteins

All aerobic organisms use oxygen and require respiratory proteins to carry out its binding, storage and transport. Respiratory proteins may be hemoglobins, hemerythrins or hemocyanins, each of which have different oxygen binding sites. A definition of the molecular basis of their activity is highly relevant to many key biological processes. Dr. Stern's broad objective is to continue the analysis of the involvement of nonheme iron in various metalloproteins using X-ray absorption fine structure spectroscopy (EXAFS). The major thrust of the research will be to develop the physical and chemical basis of the biological functions and reactivities of these metal ion containing systems. The work is both innovative and sound and has the potential of yielding significant new results.

所有需氧生物都需要氧气， 蛋白质进行其结合，储存和运输。 呼吸蛋白可以是血红蛋白、血红蛋白或血红蛋白。 血蓝蛋白，其中每一种具有不同的氧结合 网站. 对它们活动的分子基础的定义 与许多关键的生物过程密切相关。 斯特恩博士的主要目标是继续分析 非血红素铁参与各种金属蛋白 使用X射线吸收精细结构光谱（EXAFS）。 这项研究的主要目的是开发 生物功能的物理和化学基础， 这些含金属离子的系统的反应性。 工作 既创新又合理， 从而产生重要的新结果。