Metabolism of Circulating Hormones by the Fish Gill

鱼的鳃是鱼和鱼环境之间的主要接口。鳃在呼吸和调节离子和水平衡方面起着重要作用。因此，控制通过这个器官的血液流动是维持体内体液平衡的首要因素。奥尔森博士计划进行一系列研究，研究血液中通过鳃血管网络调节血流的荷尔蒙和激素样因子的作用和新陈代谢。Olson博士开发了一种鳃灌流程序，可以在存在和不存在各种药物的情况下测量血流量、血压等，这些药物包括血管紧张素、缓激肽、生物胺和其他已知的其他组织中血液流动调节剂。他已经调整了程序，这样他就能够测量这些化合物通过鳃组织的吸收和新陈代谢。然后，他将能够将血管变化与代谢事件联系起来，并确定这些因素中的哪些是调节血流的主要因素。这些研究结果对我们理解呼吸器官的血流调节具有重要意义。此外，这些结果将有助于我们了解鳃组织的激素新陈代谢，以及环境因素(即污染物)的作用，这些因素可能会损害鳃，从而扰乱通过鳃的血液流动，并扰乱应激鱼类体内的激素平衡。

The fish gill is the primary interface between the fish and the fish's environment. The gill plays a major role in respiration and in the regulation of ion and water balance. Control of blood flow through this organ is then of primary importance in the maintenance of internal body fluid homeostasis. Dr. Olson plans a series of studies on the action and metabolism of hormones and hormone-like factors in the blood that regulate blood flow through the gill vascular network. Dr. Olson has developed a gill perfusion procedure that allows measurement of blood flow, blood pressure, etc. in the presence and absence of various agents such as angiotensin, bradykinin, biogenic amines, and other compounds that are known to be regulators of blood flow in other tissues. He has adapted the procedure so that he will be able to measure the uptake and metabolism of these compounds by the gill tissue as they pass through the gill. He will then be able to correlate vascular changes with the metabolic events and determine which of these factors are the major actors in the regulation of blood flow. The research results are of primary importance to our understanding of the regulation of blood flow in respiratory organs. In addition the results will contribute to our understanding of hormone metabolism by gill tissue and to the role of environmental factors (i.e. pollutants) that might damage the gills and thereby disturb blood flow through the gills and upset hormone balance within the stressed fish.