Metabolism of Circulating Hormones by the Fish Gill

鱼鳃循环激素的代谢

• 批准号: 8616028
• 负责人: Kenneth Olson
• 金额: $ 19.84万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-01 至 1991-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8616028&HistoricalAwards=false
• 关键词: Metabolism; Circulating; Hormones; Fish; Gill

The fish gill is the primary interface between the fish and the fish's environment. The gill plays a major role in respiration and in the regulation of ion and water balance. Control of blood flow through this organ is then of primary importance in the maintenance of internal body fluid homeostasis. Dr. Olson plans a series of studies on the action and metabolism of hormones and hormone-like factors in the blood that regulate blood flow through the gill vascular network. Dr. Olson has developed a gill perfusion procedure that allows measurement of blood flow, blood pressure, etc. in the presence and absence of various agents such as angiotensin, bradykinin, biogenic amines, and other compounds that are known to be regulators of blood flow in other tissues. He has adapted the procedure so that he will be able to measure the uptake and metabolism of these compounds by the gill tissue as they pass through the gill. He will then be able to correlate vascular changes with the metabolic events and determine which of these factors are the major actors in the regulation of blood flow. The research results are of primary importance to our understanding of the regulation of blood flow in respiratory organs. In addition the results will contribute to our understanding of hormone metabolism by gill tissue and to the role of environmental factors (i.e. pollutants) that might damage the gills and thereby disturb blood flow through the gills and upset hormone balance within the stressed fish.

鱼鳃是鱼和鱼的 环境 鳃在呼吸中起着重要作用， 调节离子和水分平衡。控制血流通过 因此，该机构在维持内部安全方面具有首要重要性。 体液平衡 奥尔森博士计划进行一系列研究， 血液中激素和类激素因子的作用和代谢 调节鳃血管网的血液流动。 Olson博士 开发了一种鳃灌注程序， 在存在和不存在各种 药物如血管紧张素、缓激肽、生物胺和其它 已知在其他动物中是血流调节剂的化合物， 组织中 他已经调整了程序，这样他就可以 测量鳃组织对这些化合物的吸收和代谢 当它们通过鳃时。 然后他就能把 血管的变化与代谢事件，并确定哪些这些 这些因素是调节血流的主要因素。 研究结果对我们理解 呼吸器官中血液流动的调节。 此外 结果将有助于我们了解激素代谢， 鳃组织和环境因素（即污染物）的作用 这可能会损害鳃，从而干扰血液流动， 鱼鳃和打破荷尔蒙平衡的压力鱼。